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LE 135, Tocris Bioscience™
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Menge:
10 mg
50 mg
Beschreibung
Retinoic acid antagonist; displays moderate selectivity for RARβ over RARα (Ki values are 0.22 and 1.4 μM respectively). Highly selective over RARγ and RXRα. Inhibits human HL-60 leukemia cell differentiation induced by Am80 (IC50 = 150 nM).
Spezifikation
Spezifikation
| Chemischer Name oder Material | LE 135 |
| Menge | 10 mg |
| Synonym | chembl37708, 4-5,7,7,10,10-pentamethyl-8,9-dihydronaphtho 2,3-b 1, 4 benzodiazepin-13-yl benzoic acid, 4-5,7,7,10,10-pentamethyl-7,8,9,10-tetrahydro-5h-benzo e naphtho 2,3-b 1,4 diazepin-13-yl benzoic acid, d0x5wp, 4-7,8,9,10-tetrahydro-5,7,7,10,10-pentamethyl-5h-benzo e naphtho 2,3-b 1,4 diazepin-13-yl benzoic acid, 4-5,7,7,10,10-pentamethyl-7,8,9,10-tetrahydro-5 h-5,12-diaza-benzo 4,5 cyclohepta 1,2-b naphthalen-13-yl-benzoic acid, 4-5,7,7,10,10-pentamethyl-7,8,9,10-tetrahydro-5 h-5,12-diaza-benzo 4,5 cyclohepta 1,2-b naphthalen-13-yl-benzoic acid |
| SMILES | CN1C2=CC=CC=C2C(=NC2=C1C=C1C(=C2)C(C)(C)CCC1(C)C)C1=CC=C(C=C1)C(O)=O |
| IUPAC-Name | 4-{2,14,14,17,17-pentamethyl-2,10-diazatetracyclo[9.8.0.0³,⁸.0¹³,¹⁸]nonadeca-1(11),3,5,7,9,12,18-heptaen-9-yl}benzoic acid |
| Molekulargewicht (g/mol) | 438.57 |
| Formelmasse | 438.56 |
| Reinheit (%) | >97% |
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