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Genistein, Tocris Bioscience™

Artikelnummer. 18712804
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Menge:
10 mg
50 mg
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Beschreibung

EGFR kinase inhibitor. Also estrogen and PPARγ ligand

Genistein is a phytoestrogen with a wide range of biological actions. Genistein inhibits protein tyrosine kinases including epidermal growth factor receptor kinase, binds to PPARγ and estrogen receptors and acts as an agonist at GPER. Genistein inhibits aggregation and fibrilization of Aβ42 and amylin37 (hiAPP). In Huntington's disease fibroblast cells, Genistein reduces intracellular mutant huntingtin (mHTT) aggregates and induces degradation of mHTT; in a cellular model of Huntington's disease, Genistein corrects the mutant phenotype through stimulation of autophagy.

Chemische Identifikatoren

CAS 446-72-0
Summenformel C15H10O5
Molekulargewicht (g/mol) 270.24
MDL-Nummer MFCD00016952
InChI-Schlüssel TZBJGXHYKVUXJN-UHFFFAOYSA-N
Synonym genistein, prunetol, genisteol, 4',5,7-trihydroxyisoflavone, genisterin, sophoricol, 5,7,4'-trihydroxyisoflavone, bonistein, 5,7-dihydroxy-3-4-hydroxyphenyl-4h-chromen-4-one, genestein
PubChem CID 5280961
ChEBI CHEBI:28088
IUPAC-Name 5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one
SMILES OC1=CC=C(C=C1)C1=COC2=CC(O)=CC(O)=C2C1=O

Spezifikation

Chemischer Name oder Material Genistein
Menge 50 mg
Formelmasse 270.24
Reinheit (%) >98%
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