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Doxorubicin hydrochloride, Tocris Bioscience™

Artikelnummer. 18732474
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Menge:
10 mg
50 mg
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Antitumor antibiotic agent. Inhibits DNA topoisomerase II

Doxorubicin hydrochloride is a 14-hydroxylated version of Daunorubicin (Cat. No. 1467) that is naturally fluorescent. Doxorubicin is an antitumor antibiotic agent that inhibits DNA topoisomerase II. It is a DNA intercalator that inhibits nucleic acid synthesis and induces apoptosis. Doxorubicin reduces intracellular tau levels. Doxorubicin also promotes formation of free radicals for the disruption of membrane lipids and DNA strands. Doxorubicin fluorescence is quenched upon intercalation into the DNA; while binding to histones or partitioning into the phospholipid phase of PEG-phospholipid micelles or hydrophobic cores of polymeric micelles, increases Doxorubicin fluorescence. Doxorubicin fluorescence enables the monitoring of the localization of the drug within lipid bilayers and liposomal delivery systems and interaction of the drug with DNA and other macromolecules, as well as drug efflux pump activities.

Chemische Identifikatoren

CAS 25316-40-9
Summenformel C27H30ClNO11
Molekulargewicht (g/mol) 579.98
MDL-Nummer MFCD00077757,MFCD00077757,MFCD00941448
InChI-Schlüssel MWWSFMDVAYGXBV-FGBJBKNOSA-N
Synonym doxorubicin hydrochloride, adriamycin, doxorubicin hcl, adriacin, adriblastina, rubex, adriamycin hydrochloride, adriblastin, adriamycin pfs
PubChem CID 129626538
IUPAC-Name Hydrogen (8S,10S)-10-[(4-amin-5-hydroxy-6-methyloxan-2-yl)oxy]-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-5,7,8,9,10,12-hexahydrotetracen-5,12-dion-Chlorid
SMILES [H+].[Cl-].COC1=CC=CC2=C1C(=O)C1=C(O)C3=C(C[C@](O)(C[C@@H]3OC3CC(N)C(O)C(C)O3)C(=O)CO)C(O)=C1C2=O

Spezifikation

Chemischer Name oder Material Doxorubicin hydrochloride
Menge 10 mg
Formelmasse 579.99
Reinheit (%) >98%
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