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Zoniporide dihydrochloride, Tocris Bioscience™

Artikelnummer. 18034832
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Menge:
10 mg
50 mg
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Beschreibung

Selective NHE1 inhibitor

Sodium-hydrogen exchanger isoform 1 (NHE1) inhibitor that displays selectivity over other NHE isoforms (Ki values are 14, 2200 and 220000 nM for human NHE1, human NHE2 and rat NHE3 respectively). Inhibits NHE1 dependent 22Na+ uptake in vitro (IC50 = 14 nM) and provides cardioprotection from myocardial ischemic injury in vivo (EC50 = 0.25 nM). Also inhibits MMP2/9 activity and invasion in breast cancer cells.

Chemische Identifikatoren

CAS 241799-10-0
Summenformel C17H18Cl2N6O
Molekulargewicht (g/mol) 393.272
InChI-Schlüssel ARZNPJAGKWHEHT-UHFFFAOYSA-N
Synonym zoniporide dihydrochloride, 1-quinolin-5-yl-5-cyclopropyl-1h-pyrazole-4-carbonyl guanidine dihydrochloride
PubChem CID 22267855
IUPAC-Name 5-cyclopropyl-N-(diaminomethylidene)-1-quinolin-5-ylpyrazole-4-carboxamide;dihydrochloride
SMILES C1CC1C2=C(C=NN2C3=CC=CC4=C3C=CC=N4)C(=O)N=C(N)N.Cl.Cl

Spezifikation

Chemischer Name oder Material Zoniporide dihydrochloride
Menge 50 mg
Formelmasse 393.27
Reinheit (%) >99%
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