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SN 38, Tocris Bioscience™

Artikelnummer. 18782664
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Menge:
10 mg
50 mg
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Beschreibung

DNA topoisomerase I inhibitor; antitumor

Active metabolite of CPT-11 (Cat. No. 2688) that inhibits DNA topoisomerase I (IC50 values are 0.74 and 1.9 μM in P388 and Ehrlich cells respectively). Inhibits DNA and RNA synthesis (IC50 values are 0.077 and 1.3 μM respectively) but does not affect protein synthesis. Displays potent antitumor activity against a range of human tumor cell lines (IC50 values are 3.3, 13, 19 and 22 nM for HCT-116, BEL-7402, HL60 and HELA cells respectively).

Chemische Identifikatoren

CAS 86639-52-3
Summenformel C22H20N2O5
Molekulargewicht (g/mol) 392.411
InChI-Schlüssel FJHBVJOVLFPMQE-QFIPXVFZSA-N
Synonym 7-ethyl-10-hydroxycamptothecin, sn 38 lactone, 7-ethyl-10-hydroxy-camptothecin, 10-hydroxy-7-ethylcamptothecin, 7-ethyl-10-hydroxycamptothecine, le-sn38, 7-ethyl-10-hydroxy-20 s-camptothecin, captothecin, 7-ethyl-10-hydroxy, s-4,11-diethyl-4,9-dihydroxy-1h-pyrano 3',4':6,7 indolizino 1,2-b quinoline-3,14 4h,12h-dione, 7-ethyl-10-hydroxy camptothecin
PubChem CID 104842
ChEBI CHEBI:8988
SMILES CCC1=C2C=C(C=CC2=NC3=C1CN4C3=CC5=C(C4=O)COC(=O)C5(CC)O)O

Spezifikation

Chemischer Name oder Material SN 38
Menge 10 mg
Formelmasse 392.4
Reinheit (%) >98%
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