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Thermo Scientific™ POROS™ CaptureSelect™ AAV8 Affinity Resin

Thermo Scientific™ POROS™ CaptureSelect™ AAV8 high performance affinity resin is engineered to address the high selectivity and capacity requirements needed for the purification of viral vectors used for gene therapy applications and is specifically intended for the purification of adeno-associated virus type 8 (AAV8).

Marke:  Thermo Scientific™ A30790

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Artikelnummer. 18446678

  • 3505.00 CHF / 25 Milliliter
Verfügbar ab: 03-06-2025
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Descripción

Descripción

POROS CaptureSelect AAV8 high performance affinity resin is engineered to address the high selectivity and capacity requirements needed for the purification of viral vectors used for gene therapy applications and is specifically intended for the purification of adeno-associated virus type 8 (AAV8).

Features of POROS CaptureSelect AAV8 resin include:

  • One-step AAV8 purification from crude material with high purity and yield
  • High specificity and capacity, which helps reduce the process volume significantly for subsequent steps and maximizes yield
  • Low operating back pressure and linear pressure versus flow responses driving flexible scalability
  • Superior capacity maintained at high flow rates
  • Rigid polymeric bead with covalent surface chemistry for easier handling and packing, with superior physical and chemical stability enabling a more robust downstream purification process
  • Non-animal derived—the ligand is a 13-kDa single-domain fragment that comprises the 3 CDRs that form the antigen-binding domain and is efficiently produced by the yeast Saccharomyces cerevisiae in a production process free of animal components.

POROS CaptureSelect AAV8 affinity resin specifically binds AAV8 and enables a robust, fast, and efficient purification process with excellent purity and yield obtained in one step. The use of this affinity resin will enable significant improvement to downstream processing by reducing the purification steps and maximizing productivity, for scalability and processing consistency.

Main characteristics:

  • Matrix: cross-linked poly(styrene-divinylbenzene)
  • Average particle size: 50 μm
  • Ligand: POROS CaptureSelect AAV8 affinity ligand
  • Ligand coupling method: carbonyldiimidazole (CDI)
  • Binding capacity: >1 x 1013 genome copies/mL of resin
  • Elution conditions: acidic elution with 0.1 M glycine, pH 3.0
  • Mechanical resistance: 100 bar (1,450 psi; 10 MPa)
  • Formulation buffer: 18% (v/v) ethanol
Especificaciones

Especificaciones

>1 x 1013 genome copies/mL of resin
Store at 2°C to 8°C.
50 μm
CaptureSelect™, POROS™
Harz-
Cross-linked poly(styrene-divinylbenzene)
Nasseis
Flüssige Suspension
25 mL
AAV8 affinity ligand
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Eine Chargennummer ist erforderlich, um Ergebnisse für Zertifikate anzuzeigen. Um Ihre Chargennummer zu früheren Bestellungen zu finden, können Sie unsere Auftragsverfolgung nutzen.

5 Ergebnisse gefunden
Chargennummer Art des Zertifikats Datum Catalog Number
ChargennummerAAV8-029 Art des ZertifikatsAnalysenzertifikat Datum25/06/2024 Catalog NumberA30790
ChargennummerAAV8-028 Art des ZertifikatsAnalysenzertifikat Datum06/12/2023 Catalog NumberA30790
ChargennummerAAV8-022 Art des ZertifikatsAnalysenzertifikat Datum01/04/2021 Catalog NumberA30790
ChargennummerAAV8-020 Art des ZertifikatsAnalysenzertifikat Datum08/01/2021 Catalog NumberA30790
ChargennummerAAV8-019 Art des ZertifikatsAnalysenzertifikat Datum26/07/2019 Catalog NumberA30790
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Título del producto
Thermo Scientific™ POROS™ CaptureSelect™ AAV8 Affinity Resin > 25 mL

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