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PF 431396, Tocris Bioscience™
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Menge:
10 mg
Beschreibung
Dual focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2) inhibitor (IC50 values are 2 and 11 nM respectively). Promotes osteoblast recruitment and activity, and stimulates bone formation in ovariectomized rats.
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Spezifikation
Spezifikation
Chemischer Name oder Material | PF 431396 |
CAS | 717906-29-1 |
Summenformel | C22H21F3N6O3S |
MDL-Nummer | MFCD16038300 |
Menge | 10 mg |
Synonym | n-methyl-n-2-2-2-oxo-2,3-dihydro-1h-indol-5-yl amino-5-trifluoromethylpyrimidin-4-yl amino methyl phenyl methanesulfonamide, n-methyl-n-2-2-2-oxoindolin-5-yl amino-5-trifluoromethyl pyrimidin-4-yl amino methyl phenyl methanesulfonamide, n-methyl-n-2-2-2-oxoindolin-5-ylamino-5-trifluoromethyl pyrimidin-4-ylamino methyl phenyl methanesulfonamide, n-methyl-n-2-2-2-oxo-2,3-dihydro-1h-indol-5-yl amino-5-trifluoromethyl pyrimidin-4-yl amino methyl phenyl methanesulfonamide, 3fzr, n-methyl-n-2-2-2-oxo-1,3-dihydroindol-5-yl amino-5-trifluoromethyl pyrimidin-4-yl amino methyl phenyl methanesulfonamide, n-methyl-n-2-2-2,3-dihydro-2-oxo-1h-indol-5-yl amino-5-trifluoromethyl-4-pyrimidinyl amino methyl phenyl methanesulfonamide, n-2-2-2,3-dihydro-2-oxo-1h-indol-5-yl amino-5-trifluoromethyl-4-pyrimidinyl amino methyl phenyl-n-methyl-methanesulfonamide |
InChI-Schlüssel | POJZIZBONPAWIV-UHFFFAOYSA-N |
SMILES | CN(C1=CC=CC=C1CNC1=NC(NC2=CC3=C(NC(=O)C3)C=C2)=NC=C1C(F)(F)F)S(C)(=O)=O |
IUPAC-Name | N-methyl-N-{2-[({2-[(2-oxo-2,3-dihydro-1H-indol-5-yl)amino]-5-(trifluoromethyl)pyrimidin-4-yl}amino)methyl]phenyl}methanesulfonamide |
Molekulargewicht (g/mol) | 506.50 |
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