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(+)-MK 801 maleate, Tocris Bioscience™

Artikelnummer. 30001147
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Menge:
10 mg
50 mg
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Beschreibung

Non-competitive NMDA antagonist; acts at ion channel site

(+)-MK 801 maleate is a high affinity (Ki = 37.2 nM), selective and non-competitive NMDA receptor antagonist. (+)-MK 801 maleate acts by binding to a site located within the NMDA associated ion channel and thus prevents Ca2+ flux. It is an effective anti-ischemic agent in several animal models. (+)-MK 801 maleate increases motor activity in rat models. (+)-MK 801 maleate inhibits proliferation and increases apoptosis in hippocampal neural stem cells (NSCs). (+)-MK 801 maleate induces schizophrenia-like symptoms in rodents.

(-)-enantiomer also available.

Chemische Identifikatoren

CAS 77086-22-7
Summenformel C20H19NO4
Molekulargewicht (g/mol) 337.375
InChI-Schlüssel QLTXKCWMEZIHBJ-PJGJYSAQSA-N
Synonym dizocilpine maleate, +-mk-801 hydrogen maleate, +-mk 801 maleate, dizocilpine hydrogen maleate, unii-6lr8c1b66q, dizocilpine maleate usan, dsstox_cid_25785, dsstox_rid_81126
PubChem CID 6420042
SMILES CC12C3=CC=CC=C3CC(N1)C4=CC=CC=C24.C(=CC(=O)O)C(=O)O

Spezifikation

Chemischer Name oder Material (+)-MK 801 maleate
Menge 10 mg
Formelmasse 337.37
Reinheit (%) >99%
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