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Hygromycin B, Thermo Scientific Chemicals

Artikelnummer. 15403419
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Menge:
100 mg
250 mg
1 g
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Beschreibung

Ein Aminoglykosid-Antibiotikum, das Bakterien abtötet, indem es die Proteinsynthese hemmt

An aminoglycoside antibiotic that kills bacteria by inhibiting protein synthesisHygromycin B is used for the selection and maintenance of prokaryotic and eukaryotic cells that contains the hygromycin resistance gene. This gene is frequently used as a selectable marker in research on plants. It stabilizes the transfer ribonucleic acid (tRNA)-ribosomal acceptor site, thereby inhibiting translocation. In addition to this, it serves as an aminoglycosidic antibiotic which inhibits protein synthesis.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

  • Hygromycin is an aminoglycosidic compound that shows antibiotic activity. It is produced by Streptomyces hygroscopicus
  • Hygromycin acts against both prokaryotic and eukaryotic cells, having the ability to inhibit protein synthesis. It also stabilizes the transfer ribonucleic acid (tRNA)-ribosomal acceptor site, thereby inhibiting translocation. This compound prevents ribosome translocation during translation elongation by binding the 30S rRNA proximal to the ribosomal E, P, and A sites

Application

  • In clinical and plant research, this compound can be used as a marker to select and maintain prokaryotic and eukaryotic cells containing the hygromycin resistance gene
  • Hygromycin also presents an anthelmintic activity against nematode parasites of chickens
TRUSTED_SUSTAINABILITY

Chemische Identifikatoren

CAS 31282-04-9
Summenformel C20H37N3O13
Molekulargewicht (g/mol) 527.524
MDL-Nummer MFCD06795479
InChI-Schlüssel GRRNUXAQVGOGFE-BBMONYMYSA-N
PubChem CID 134129613
IUPAC-Name (3'S,3aS,4S,4'S,5'R,6R,6'R,7R,7aS)-4-[(1R,2S,3R,5S,6S)-3-Amino-2,6-Dihydroxy-5-(methylamino)cyclohexyl]oxy-6'-[(1S)-1-Amino-2-Hydroxyethyl]-6-(hydroxymethyl)spiro[4,6,7,7a-tetrahydro-3aH-[1,3]dioxolo[4,5-c]pyran-2,2'-oxan]-3',4',5',7-tetrol
SMILES CNC1CC(C(C(C1O)OC2C3C(C(C(O2)CO)O)OC4(O3)C(C(C(C(O4)C(CO)N)O)O)O)O)N

Spezifikation

Chemischer Name oder Material Hygromycin B
Typ Hygromycin B
Physikalische Form Lyophilized Powder
UN-Nummer UN3462
Merck Index 14,4852
Löslichkeitsinformationen Miscible with water,methanol,buffer solution and ethanol; Immiscible with less polar solvents.
Formelmasse 527.53
Farbe Braun
Menge 100 mg

RUO – Research Use Only

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