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Gibco™ Human FGF-basic (FGF-2/bFGF) (154 aa) Recombinant Protein, PeproTech®
Recombinant Protein
Marke: Gibco™ 100-18B-50UG
157.50 CHF gültig bis 2025-03-16
Benutzen Sie den Promotions-Code "24070" um Ihren Promotions-Preis zu erhalten.
Beschreibung
Recombinant Human FGF-basic is a 17.2 kDa protein consisting of 154 amino acid residues. Qualified for stem cell use. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis
FGF2 (FGFb, fibroblast growth factor basic) belongs to the fibroblast growth factor (FGF) family, and interacts with high-affinity transmembrane receptors to influence cell proliferation and tissue neovascularization. FGF2 exists as five isoforms with distinct intracellular localizations and functions. The 18 kDa isoform is predominantly cytosolic and acts through cell surface receptors, whereas the 22, 22.5, 24 and 34 kDa isoforms are nuclear and may signal independent of transmembrane receptor pathways. In humans, the gene is located on the q arm of chromosome 4. FGF2 has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for FGF2 contains multiple polyadenylation sites, and is alternatively translated from non-AUG and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF. Diseases associated with FGF2 dysfunction include Kaposi Sarcoma and corneal neovascularization.
Spezifikation
P09038 | |
protein with no preservative | |
17.2 kDa | |
50 μg | |
-20°C | |
<1 EU/ μg | |
FGF2 | |
Determined by a cell proliferation assay using Balb/c 3T3 cells. The expected ED50 is ≤ 0.1 ng/ml, corresponding to a specific activity of ≥ 1 x 10^7 units/mg | |
Recombinant | |
-20°C | |
Lyophilized |
ELISA, Functional Assay, Western Blot | |
2247 | |
Human FGF-basic (FGF-2/bFGF) (154 aa) | |
E. coli | |
RUO | |
Basic fibroblast growth factor; basic fibroblast growth factor bFGF; bFGF; FGF; fgf basic; Fgf2; Fgf-2; Fgfb; FGF-b; Fibroblast growth factor; fibroblast growth factor 2; fibroblast growth factor 2 (basic); HBGF-2; Heparin-binding growth factor 2; H-FGF-b-147; H-FGF-b-154; M-FGF-b; Prostatic growth factor; prostatropin | |
FGF2 | |
Unconjugated | |
AAGSITTLPA LPEDGGSGAF PPGHFKDPKR LYCKNGGFFL RIHPDGRVDG VREKSDPHIK LQLQAEERGV VSIKGVCANR YLAMKEDGRL LASKCVTDEC FFFERLESNN YNTYRSRKYT SWYVALKRTG QYKLGSKTGP GQKAILFLPM SAKS | |
E. coli | |
≥ 95% by SDS-PAGE gel and HPLC analyses. |
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