Recombinant Protein
Marke: Gibco™ PHG0311L
Carrier-Free
EGF (Epidermal growth factor) exerts its actions by binding to the EGF Receptor, a 170 kDa protein kinase. Activation of EGFR initiates diverse cellular pathways in response to toxic environmental stimuli, or to EGF binding to the receptor, the EGFR forms homo- or heterodimers with other family members. Each dimeric receptor complex initiates a distinct signaling pathway by recruiting different Src homology 2 (SH2) containing effector proteins. EGF is far and wide expressed in kidney, cerebrum, prostrate and salivary glands. EGF acts as a potent mitogenic factor and the phosphorylated receptor recruits adapter proteins like GRB2 that activates complex downstream signaling cascades. EGF activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STAT modules. Research studies suggest the protein may also play important role in activating the NF-kappa-B signaling cascade. Defects in the EGGF gene are the cause of hypomagnesemia type 4 and dysregulation has been associated with the growth and progression of certain cancers.
| P01133 | |
| Control, ELISA, Functional Assay, Immunohistochemistry, Western Blot | |
| 1950 | |
| Human EGF | |
| 100 μg | |
| AI790464; beta-urogastrone; EGF; Epidermal growth factor; epidermal growth factor (beta-urogastrone); epidermal growth factor precursor; H-EGF; HOMG4; Pro-epidermal growth factor; Pro-epidermal growth factor precursor (EGF); sb:eu639; URG; Urogastrone | |
| ED50 < 0.4 ng/mL; determined by the dose-dependent proliferation of mouse BALB/3T3 cells. | |
| Human | |
| NSDSECPLSH DGYCLHDGVC MYIEALDKYA CNCVVGYIGE RCQYRDLKWW ELR | |
| Carrier-Free | |
| Balb/3T3 cells | |
| Dry Ice | |
| E. coli | |
| Recombinant, Ligand | |
| EGF (Epidermal Growth Factor) | |
| Gibco™ |
| 1 mg/mL | |
| PBS with no preservative | |
| 6.2 kDa | |
| Sequential Chromatography | |
| <0.1 ng/ μg | |
| EGF | |
| Unconjugated | |
| Recombinant | |
| -20°C, Avoid Freeze/Thaw Cycles | |
| <0.1 ng/μg | |
| Human | |
| 1.0 x 107 - 2.5 x 106 units⁄mg | |
| Growth Factors & Receptors | |
| Liquid | |
| Stem Cell Research, Oncology | |
| >95% by SDS-PAGE |
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