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Cytiva™ HiScreen™ Column with MabSelect™ VL Protein L Resin
Diese HiScreen™ Säulen enthalten Protein L-Harz zur Affinitätserfassung von FABs-Antikörpern, bispezifischen und anderen Varianten, die eine Kappa-Leichtkette enthalten.
Marke: Cytiva™ 17542015
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Beschreibung
As the diversity of antibody variants increases, so does the need for chromatography resins that can capture and purify these variants. As an alternative to protein A, protein L resin can be used to capture antibody Fabs, bispecific antibodies, and other molecules containing kappa variants of the variable light (VL) chain. Protein L binds human kappa light chain subtypes 1, 3, and 4 and mouse kappa light chain subtype 1.
Redesigned protein L ligand MabSelect™ VL protein L resin showed a two-fold increase in binding capacity compared to Cytiva™ Capto™ L chromatography resin. This higher capacity provides productivity advantages in research and biomanufacturing.
- A redesigned protein L ligand captures antibody Fabs, bispecifics, and other variants containing a kappa light chain with high binding capacity and improved alkaline stability
- High dynamic binding capacity for efficient capture of target molecules
- Stable when cleaned with 0.1 M NaOH, reducing risk for bioburden incidents
- Provides good resolution for product-related impurities in the capture of bispecific antibodies
- Convenient for method optimization and parameter screening enabled by the 10 cm bed height for efficient chromatography process development
Spezifikation
| 70 mg Human-IgG/ml-Harz bei 6 Minuten Verweilzeit, 60 mg Human-IgG/ml-Harz bei 4 Minuten Aufenthaltszeit | |
| 0.3 in. | |
| <300 cm/hr. | |
| 60 μm | |
| 1 Column | |
| Antikörper | |
| Chromatographiesäule | |
| Affinity |
| 4.7 mL | |
| 7.7 mm | |
| 3 bar | |
| HiScreen™ MabSelect™ | |
| Antikörper-Affinitätschromatographie | |
| Vorgepackte Säule | |
| 100 mm |