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Tocris Bioscience™ GSK 2830371
Potent and selective allosteric inhibitor of Wip1 phosphatase
318.00 CHF
Spezifikation
| Reinheit | >98% |
|---|---|
| Produkttyp | GSK 2830371 |
| Molekulargewicht | 461.02 |
| Hemmstoffe | GSK 2830371 |
| Produktcode | Marke | Menge | Preis | Menge & Verfügbarkeit | |||||
|---|---|---|---|---|---|---|---|---|---|
| Produktcode | Marke | Menge | Preis | Menge & Verfügbarkeit | |||||
|
18762978
|
Tocris Bioscience™
5140/10 |
10 mg |
318.00 CHF
10 Milligramm |
Verfügbar ab: 19-12-2024
Loggen Sie sich ein, um den Lagerbestand zu sehen |
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Beschreibung
Potent and selective allosteric inhibitor of Wip1 phosphatase (IC50 = 6 nM). Exhibits selectivity for Wip1 over 21 other phosphatases. Increases phosphorylation of Wip1 substrates, including p53, Chk2, H2AX and ATM. Attenuates tumor cell growth in a variety of lymphoid cell lines. Also inhibits lymphoma xenograft growth in vivo. Potentiates growth inhibitory effects of MDM2 inhibition in cancer cell lines in a p53-dependent manner. Orally bioavailable.Spezifikation
| >98% | |
| GSK 2830371 | |
| 461.02 | |
| GSK 2830371 |
Nur für Forschungszwecke