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Tocris Bioscience™ GSK 2830371
Potent and selective allosteric inhibitor of Wip1 phosphatase
Marke: Tocris Bioscience™ 5140/10
250.54 CHF gültig bis 2024-12-16
Benutzen Sie den Promotions-Code "21630" um Ihren Promotions-Preis zu erhalten.
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Beschreibung
GSK 2830371 is a potent and selective allosteric inhibitor of Wip1 phosphatase (IC50 = 6 nM). Exhibits selectivity for Wip1 over 21 other phosphatases. Increases phosphorylation of Wip1 substrates, including p53, Chk2, H2AX and ATM. Attenuates tumor cell growth in a variety of lymphoid cell lines. Also inhibits lymphoma xenograft growth in vivo. Potentiates growth inhibitory effects of MDM2 inhibition in cancer cell lines in a p53-dependent manner. Orally bioavailable.Spezifikation
| >98% | |
| GSK 2830371 | |
| GSK 2830371 |
| 10 mg | |
| 461.02 |
Nur für Forschungszwecke