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Thermo Scientific™ GeneBLAzer™ ENDRB-NFAT-bla HEK 293T Cells
GeneBLAzer™ EDNRB-NFAT-bla HEK293T cells contain the human Endothelin Type B Recpetor (EDNRB) stably integrated into the CellSensor™ NFAT-bla HEK293T cell line.
Marke: Thermo Scientific™ K1727
Beschreibung
GeneBLAzer™ EDNRB-NFAT-bla HEK293T cells contain the human Endothelin Type B Recpetor (EDNRB) stably integrated into the CellSensor™ NFAT-bla HEK293T cell line. CellSensor™ NFAT-bla HEK293T cells (Cat. No. K1538) contain a beta-lactamase reporter gene under control of the Nuclear Factor of Activated T-cells (NFAT) response element.
The GeneBLAzer™ EDNRB-NFAT-bla HEK293T cells are functionally validated for Z' and EC50 concentrations of ET-1. In addition, GeneBLAzer™ EDNRB-NFAT-bla HEK293T cells have been tested for assay performance under variable conditions. These data are found in the Validation & Assay Performance Summary.
The ENDRB receptor mediates signaling of endothelin proteins that regulate several critical biological processes, including the development and function of blood vessels, the production of certain hormones, and the stimulation of cell growth and division. Defects in EDNRB mediated signaling have been implicated in a wide range of diseases, including cancer, hypertension and cardiovascular disorders.
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Spezifikation
NM_000115.1 | |
Teilende Zellen | |
Fluoreszent | |
EDNRB | |
Auf Einzelzellen basierende Klone | |
2 x 106 Zellen | |
EDNRB | |
293T (HEK) | |
GPCRs |
Zellbasiertes Beta-Lactamase-Reportergen | |
Inhalt: K1727 GeneBLAzer™ EDNRB-NFAT-bla HEK293T-Zellen (LiveBLAzer™-FRET B⁄G Ladekit, Lösung D und andere Materialien sind separat erhältlich; siehe Protokoll). Enthält: • GeneBLAzer™ EDNRB-NFAT-bla HEK293T-Zellen • GeneBLAzer™ EDNRB-NFAT-bla HEK293T Assay-Protokoll • Analysenzertifikat Lagerung: Die GeneBLAzer™ GeneBLAzer™ EDNRB-NFAT-bla HEK293T-Zellen werden auf Trockeneis geliefert und sollten sofort nach Erhalt in flüssigem Stickstoff gelagert werden. |
|
FRET | |
EDNRB-NFAT-bla HEK293T-Zellen, EDNRB-NFAT-bla HEK293T Assay-Protokoll, Analysenzertifikat | |
GeneBLAzer™ | |
BLA (Beta-Lactamase) | |
ENDRB-NFAT-bla HEK 293T-Zelle | |
GeneBLAzer™ |
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Nur für Forschungszwecke. Nicht zur Verwendung bei diagnostischen Verfahren.