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Clozapine, Tocris Bioscience™

Artikelnummer. 18722784
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Menge:
50 mg
500 mg
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Beschreibung

Dopamine antagonist with some D4 selectivity; also 5-HT2A/2C antagonist

Clozapine is an atypical antipsychotic drug, with a much lower tendency to cause extrapyramidal side effects than conventional neuroleptics. Displays a broad range of pharmacological actions; the antipsychotic effects are thought to be mediated principally by 5-HT2A/2C and dopamine receptor blockade (Ki values are 21, 170, 170, 230 and 330 nM for D4, D3, D1, D2 and D5 receptors respectively).

Chemische Identifikatoren

CAS 5786-21-0
Summenformel C18H19ClN4
Molekulargewicht (g/mol) 326.828
InChI-Schlüssel ZUXABONWMNSFBN-UHFFFAOYSA-N
Synonym clozapine, leponex, clozapin, clozaril, fazaclo, clorazil, iprox, clozapinum, asaleptin, clozapina
PubChem CID 2818
IUPAC-Name 3-chloro-6-(4-methylpiperazin-1-yl)-5H-benzo[b][1,4]benzodiazepine
SMILES CN1CCN(CC1)C2=C3C=CC=CC3=NC4=C(N2)C=C(C=C4)Cl

Spezifikation

Chemischer Name oder Material Clozapine
Menge 50 mg
Formelmasse 326.83
Reinheit (%) >99%
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