missing translation for 'onlineSavingsMsg'
Learn More
  1. Home
  2. Products
  3. Chemikalien
  4. Organische Verbindungen
  5. Benzoide
  6. Benzol und substituierte Derivate
  7. N-Phenylharnstoffe
  8. BX 471, Tocris Bioscience™

BX 471, Tocris Bioscience™

Artikelnummer. 30001487
Click to view available options
Menge:
10 mg
50 mg
Dieser Artikel kann nicht zurückgegeben werden. Rückgaberichtlinie anzeigen
Dieser Artikel kann nicht zurückgegeben werden. Rückgaberichtlinie anzeigen

Beschreibung

Potent, selective CCR1 antagonist

Potent, selective non-peptide CCR1 antagonist (Ki = 1 nM for human CCR1). Exhibits 250-fold selectivity for CCR1 over CCR2, CCR5 and CXCR4. Inhibits MIP-α/CCL3-induced intracellular Ca2+ mobilization. Orally active; effectively reduces disease severity in a rat model of multiple sclerosis. Decreases renal fibrosis in a mouse model of obstructive nephropathy.

Chemische Identifikatoren

CAS 217645-70-0
Summenformel C21H24ClFN4O3
Molekulargewicht (g/mol) 434.896
InChI-Schlüssel XQYASZNUFDVMFH-CQSZACIVSA-N
Synonym ZK-811752, unii-76k17zg4zn, r-1-5-chloro-2-2-4-4-fluorobenzyl-2-methylpiperazin-1-yl-2-oxoethoxy phenyl urea, 5-chloro-2-2-2r-4-4-fluorophenyl methyl-2-methylpiperazin-1-yl-2-oxoethoxy phenyl urea, n-5-chloro-2-2-2r-4-4-fluorophenyl methyl-2-methyl-1-piperazinyl-2-oxoethoxy phenyl-urea, urea, n-5-chloro-2-2-2r-4-4-fluorophenyl methyl-2-methyl-1-piperazinyl-2-oxoethoxy phenyl, bx-471free base, d05xzf, gtpl767
PubChem CID 512282
IUPAC-Name [5-chloro-2-[2-[(2R)-4-[(4-fluorophenyl)methyl]-2-methylpiperazin-1-yl]-2-oxoethoxy]phenyl]urea
SMILES CC1CN(CCN1C(=O)COC2=C(C=C(C=C2)Cl)NC(=O)N)CC3=CC=C(C=C3)F

Spezifikation

Chemischer Name oder Material BX 471
Menge 50 mg
Formelmasse 434.89
Reinheit (%) >98%
missing translation for 'provideContentCorrection'

missing translation for 'type03FormHeader'

missing translation for 'productTitle'

missing translation for 'byClickingSubmit' missing translation for 'privacyPolicy'.

missing translation for 'thankYou' missing translation for 'feedbackSubmitted'