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XMD 8-92, Tocris Bioscience™

Artikelnummer. 18084252
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Menge:
10 mg
50 mg
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Beschreibung

ERK5/BMK1 inhibitor; also BRD4 inhibitor

ERK5 (BMK1) and BRD4 inhibitor (Kd values are 80 and 190 nM, respectively). Also inhibits DCAMKL2, PLK4 and TNK1 (Kd values are 190, 600 and 890 nM). Blocks growth factor-induced activation of cellular BMK1 and reduces BMK1 activity in in vitro kinase assays. Also reduces BMK1-dependent transactivating activity of MEF2C. Inhibits proliferation in a variety of cancer cell lines; blocks tumor cell proliferation and tumor-associated angiogenesis.

Chemische Identifikatoren

CAS 1234480-50-2
Summenformel C26H30N6O3
Molekulargewicht (g/mol) 474.565
InChI-Schlüssel QAPAJIZPZGWAND-UHFFFAOYSA-N
Synonym 2-2-ethoxy-4-4-hydroxy-1-piperidinyl phenyl amino-5,11-dihydro-5,11-dimethyl-6h-pyrimido 4,5-b 1,4 benzodiazepin-6-one, 2-2-ethoxy-4-4-hydroxypiperidin-1-yl anilino-5,11-dimethylpyrimido 4,5-b 1,4 benzodiazepin-6-one, 2-2-ethoxy-4-4-hydroxypiperidin-1-yl phenyl amino-5,11-dimethyl-5,11-dihydro-6h-pyrimido 4,5-b 1,4 benzodiazepin-6-one, 2-2-ethoxy-4-4-hydroxypiperidin-1-yl phenyl amino-5,11-dimethyl-5h-benzo e pyrimido 5,4-b 1,4 diazepin-6 11h-one, scaffold, b46, d0m0qq, xmd 8-92 free base, xmd hplc, 2-2-ethoxy-4-4-hydroxypiperidin-1-yl anilino-5,11-dimethyl-5,11-dihydro-6h-pyrimido 4,5-b 1,4 benzodiazepin-6-one, 5-2-ethoxy-4-4-hydroxypiperidin-1-yl phenyl amino-2,9-dimethyl-2,4,6,9-tetraazatricyclo 9.4.0.0 3 ,? pentadeca-1 15 ,3,5,7,11,13-hexaen-10-one
PubChem CID 46843772
ChEBI CHEBI:60325
IUPAC-Name 2-[2-ethoxy-4-(4-hydroxypiperidin-1-yl)anilino]-5,11-dimethylpyrimido[4,5-b][1,4]benzodiazepin-6-one
SMILES CCOC1=C(C=CC(=C1)N2CCC(CC2)O)NC3=NC=C4C(=N3)N(C5=CC=CC=C5C(=O)N4C)C

Spezifikation

Chemischer Name oder Material XMD 8-92
Menge 10 mg
Formelmasse 474.55
Reinheit (%) >98%
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