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TIM-4 Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Marke: Thermo Scientific PA5116045
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Beschreibung
Antibody detects endogenous levels of total TIM 4.
The T cell immunoglobulin and mucin domain containing protein (TIM) family encodes cell surface receptors that are involved in the regulation of T helper (Th) -1 and -2 cell-mediated immunity. TIM-4, which is preferentially expressed on macrophages and dendritic cells, is the natural ligand of TIM-1, and this binding leads to T-cell expansion and cytokine production. Unlike other members of the TIM family, TIM-4 lacks a putative tyrosine phosphorylation signal sequence in its intracellular domain. The TIM-4 gene maps to a locus associated with predisposition to asthma in both mice and humans and with its connection to TIM-1-triggered Th2 responsiveness, may be considered as a candidate disease/predisposition gene for asthma.Spezifikation
TIM-4 | |
Polyclonal | |
Unconjugated | |
TIMD4 | |
B430010N18Rik; RGD1564516; smuckler; soluble TIM 4; Spleen, mucin-containing, knockout of lymphotoxin protein; sTIM 4; T cell immunoglobulin and mucin domain containing 4; T-cell immunoglobulin and mucin domain containing 4; T-cell immunoglobulin and mucin domain-containing protein 4; T-cell immunoglobulin mucin receptor 4; T-cell membrane protein 4; Tim4; TIM-4; TIMD4; TIMD-4 | |
Rabbit | |
Affinity chromatography | |
RUO | |
276891, 497891, 91937 | |
-20°C | |
Liquid |
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot | |
1 mg/mL | |
PBS with 50% glycerol and 0.02% sodium azide | |
Q6U7R4, Q96H15 | |
TIMD4 | |
A synthesized peptide derived from human TIMD4(Accession Q96H15), corresponding to amino acid residues S272-S322. | |
100 μL | |
Primary | |
Human, Mouse, Rat | |
Antibody | |
IgG |