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TIM-3 Monoclonal Antibody (1E5), Invitrogen™
Mouse Monoclonal Antibody
Marke: Invitrogen MA532841
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Beschreibung
Mouse Monoclonal Antibody
TIM3 (Hepatitis A virus cellular receptor 2, HAVCR2, T-cell immunoglobulin, mucin-dmain containing-3) is a 281 amino acid long, Type-1 Th1- specific cell surface glycoprotein expressed on terminally differentiated CD4+Th1 and CD8+Tc1 cells. TIM3 consists of an IgV-like domain, a mucin-like domain in the extracellular region, and a conserved Tyrosine phosphorylation motif in the cytoplasmic region. TIM3 is involved in macrophage activation and induction of autoimmune diseases. Further, TIM3 down-regulates aggressive Th1-mediated immune responses and facilitates in the development of immune tolerance. Pathological significance of TIM3 has been attributed to Experimental autoimmune encephalomyelitis (EAE), a Th-1 dependent autoimmune disease, and also enhances the severity of experimental autoimmune encephalomyelitis in mice.
Spezifikation
| TIM-3 | |
| Monoclonal | |
| 2 mg/mL | |
| PBS with 0.2% BSA, 50% Glycerol and 0.05% sodium azide, pH 7.4 | |
| Q8TDQ0 | |
| Havcr2 | |
| Recombinant protein with Human Tim3 1-89 | |
| 100 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG1 |
| Flow Cytometry, Immunocytochemistry, Immunohistochemistry, Western Blot, Western Blot | |
| 1E5 | |
| Unconjugated | |
| Havcr2 | |
| CD366, FLJ14428, Havcr2, HAVcr-2, Hepatitis A virus cellular receptor 2, hepatitis A virus cellular receptor 2 homolog, kidney injury molecule-3, KIM-3, sCD366, soluble CD366, soluble TIM 3, T cell immunoglobulin mucin 3, T cell immunoglobulin mucin-3, T-cell immunoglobulin and mucin domain containing 3, T-cell immunoglobulin and mucin domain-containing protein 3, T-cell immunoglobulin mucin family member 3, T-cell immunoglobulin mucin receptor 3, T-cell membrane protein 3, Tim3, TIM-3, TIMD3, TIMD-3 | |
| Mouse | |
| Protein A | |
| RUO | |
| 84868 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |