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JNJ 17203212, Tocris Bioscience™

Artikelnummer. 18084422
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10 mg
50 mg
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Beschreibung

Reversible, competitive and potent TRPV1 antagonist

Reversible, competitive and potent TRPV1 antagonist (pKi values are 6.5, 7.1 and 7.3 at rat, guinea pig and human TRPV1 respectively). Inhibits capsaicin- and H+-induced channel activation (pIC50 values are 6.32 and 7.23 respectively) and exhibits antitussive and analgesic activity in vivo.

Chemische Identifikatoren

CAS 821768-06-3
Summenformel C17H15F6N5O
Molekulargewicht (g/mol) 419.331
InChI-Schlüssel JFRYYGVYCWYIDQ-UHFFFAOYSA-N
Synonym unii-71je0c439x, 4-3-trifluoromethyl pyridin-2-yl-n-5-trifluoromethyl pyridin-2-yl piperazine-1-carboxamide, 4-3-trifluoromethyl-pyridin-2-yl-piperazine-1-carboxylic acid 5-trifluoromethyl-pyridin-2-yl-amide, d0dy4e, compound 41 pmid: 15771431, 1-piperazinecarboxamide, 4-3-trifluoromethyl-2-pyridinyl-n-5-trifluoromethyl-2-pyridinyl, 4-3-trifluoromethyl pyridin-2-yl piperazine-1-carboxylic acid 5-trifluoromethyl pyridin-2-yl amide, n1-3-trifluoromethylpyrid-2-yl-n4-4-trifluoromethylpyrid-2-yl carbamoylpiperazine, 4-3-trifluoromethyl-2-pyridinyl-n-5-trifluoromethyl-2-pyridinyl-1-piperazinecarboxamide
PubChem CID 11339118
IUPAC-Name 4-[3-(trifluoromethyl)pyridin-2-yl]-N-[5-(trifluoromethyl)pyridin-2-yl]piperazine-1-carboxamide
SMILES C1CN(CCN1C2=C(C=CC=N2)C(F)(F)F)C(=O)NC3=NC=C(C=C3)C(F)(F)F

Spezifikation

Chemischer Name oder Material JNJ 17203212
Menge 50 mg
Formelmasse 419.32
Reinheit (%) >99%
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