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Gibco™ Human IL-10, Animal-Free Recombinant Protein, PeproTech®
Recombinant Protein
Marke: Gibco™ AF-200-10-250UG
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Beschreibung
IL-10 encodes a protein that acts as a cytokine and is primarily produced by monocytes, with some production by lymphocytes. This cytokine has various effects on immunoregulation and inflammation, including down-regulating the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. Additionally, IL-10 can block NF-kappa B activity and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice have suggested that this cytokine is an essential immunoregulator in the intestinal tract. Mutations in this gene have been associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis. Diseases associated with IL10 include Graft-Versus-Host Disease and Human Immunodeficiency Virus Type 1.
Spezifikation
| P22301 | |
| Lyophilized | |
| 3586 | |
| IL10 | |
| 250 μg | |
| RUO | |
| CSIF; cytokine; Cytokine synthesis inhibitory factor; GVHDS; H-IL-10; il 10; IL10; IL-10; IL-10 precursor; IL10A; IL10X; ILN; Interleukin; interleukin 10; Interleukin10; interleukin-10; MGC126450; MGC126451; RP11-262N9.1; T-cell growth inhibitory factor; TGIF | |
| Protein | |
| Unconjugated | |
| MSPGQGTQSE NSCTHFPGNL PNMLRDLRDA FSRVKTFFQM KDQLDNLLLK ESLLEDFKGY LGCQALSEMI QFYLEEVMPQ AENQDPDIKA HVNSLGENLK TLRLRLRRCH RFLPCENKSK AVEQVKNAFN KLQEKGIYKA MSEFDIFINY IEAYMTMKIR N | |
| E. coli |
| Functional Assay | |
| protein with no preservative | |
| 18.6 kDa | |
| HPLC, SDS-PAGE | |
| -20°C | |
| <0.1 EU/ μg | |
| IL10 | |
| Human | |
| Recombinant | |
| Determined by the dose-dependent co-stimulation (with human IL-4) of MC/9 cells. The expected ED50 is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 10^5 units/mg | |
| ≥ 98% by SDS-PAGE gel and HPLC analyses. |
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