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Thermo Scientific™ GeneBLAzer™ MR-UAS-bla HEK293T-Zellen
MR-UAS-bla HEK 293T cells contain the ligand-binding domain (LBD) of the human Mineralcorticoid Receptor (MR) fused to the NA-binding domain of GAL4 stably integrated in the GeneBLAzer™UAS-bla HEK 293T cell line.
Marke: Thermo Scientific™ K1696
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Beschreibung
MR-UAS-bla HEK 293T cells contain the ligand-binding domain (LBD) of the human Mineralcorticoid Receptor (MR) fused to the NA-binding domain of GAL4 stably integrated in the GeneBLAzer™UAS-bla HEK 293T cell line. GeneBLAzer™UAS-bla HEK 293T cells stably express a beta-lactamase reporter gene under the transcriptional control of an upstream activator sequence (UAS). When an agonist binds to the LBD of the GAL4 (DBD)-MR (LBD) fusion protein, the protein binds to the UAS, resulting in expression of beta-lactamase. Division Arrested (DA) cells are available in two configurations- an Assay Kit (which includes cells and sufficient substrate to analyze 1 x 384- well plate), and a tube of cells sufficient to analyze 10 x 384-well plates. MR-UAS-bla HEK 293T cells are functionally validated for Z' and EC50 concentrations of aldosterone. In addition, MR-UAS-bla HEK 293T cells have been tested for assay performance under variable conditions, including DMSO concentration, cell number, and substrate loading time. Additional testing data using alternate stimuli are also available.
Spezifikation
| AM 580, Fenretinid, 9-cis-Retinsäure, Ch 55, TTNPB | |
| Zellbasiertes Beta-Lactamase-Reportergen | |
| Flüssigstickstoff | |
| GeneBLAzer™ MR-UAS-bla HEK 293T-Zellen, 2 x 106 Zellen, LE 135-Antagonisten, Fluoreszenznachweisverfahren, Zellkern-Reporter Druggable Target, BLA (Beta-Lactamase)-Reporter, Lagerung in Flüssigstickstoff | |
| Kernrezeptoren, nukleäre Rezeptoren | |
| 2 x 106 Cells | |
| GeneBLAzer™ | |
| HEK 293T-Zelle | |
| BLA (Beta-Lactamase) | |
| GeneBLAzer™ MR-UAS-bla HEK 293T-Zellen |
| LE 135 | |
| Teilende Zellen | |
| Fluoreszent | |
| Pharmazie und Biopharmazie, Arzneimittelforschung und -entwicklung, Ziel- und Verlaufserkennung und -validierung, G-Protein-gekoppelte Rezeptorbiologie, zellbasierte GPCR-Reporter-Assays | |
| GeneBLAzer™ MR-UAS-bla HEK293T-Zellen enhalten: MR-UAS-bla HEK 293T-Zellen, Protokoll, Analysenzertifikat | |
| all-trans-Retinsäure | |
| 2 x 106 Zellen | |
| 293T (HEK) | |
| NR3C2, MR |
Nur für Forschungszwecke. Nicht zur Verwendung bei diagnostischen Verfahren.