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Thermo Scientific™ GeneBLAzer™ EDG3-Gα15-NFAT-bla HEK 293T Cells
GeneBLAzer™ EDG3-Gα15-NFAT-bla HEK293T cells contain the human Endothelial Differentiation Receptor 3 (EDG3) stably integrated into the GeneBLAzer™ EDG3-Gα15-NFAT-bla HEK293T cell line.
Marke: Thermo Scientific™ K1713
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Beschreibung
GeneBLAzer™ EDG3-Gα15-NFAT-bla HEK293T cells contain the human Endothelial Differentiation Receptor 3 (EDG3) stably integrated into the GeneBLAzer™ EDG3-Gα15-NFAT-bla HEK293T cell line. GeneBLAzer™ Gα15-NFAT-bla HEK293T cells (Cat. No. K1539) contain a beta-lactamase reporter gene under control of the Nuclear Factor of Activated T-cells (NFAT) response element and the Promiscuous G protein, Gα15.
The GeneBLAzer™ EDG3-Gα15-NFAT-bla HEK293T cells are functionally validated for Z' and EC50 concentrations of S1P. In addition, GeneBLAzer™ EDG3-Gα15-NFAT-bla HEK293T cells have been tested for assay performance under variable conditions. These data are found in the Validation & Assay Performance Summary.
EDG-3/S1P-3(Sphingosine-1-Phosphate-3) is a Gq/Gi/Go/Gα13/Gα12 coupled GPCR. EDG-3 has been shown to be responsible for bradycardia that has been induced in clinical trials as a side effect of the immunosuppressive drug FTY720 that targets EDG-1. EDG-3 has also been shown to induce vasodilation in response to sphingosylphosphorylcholine (SPC), sphingosine-1-phosphate (S1P), and lysosulfatide (LSF). The EDG-3 Receptor has also been shown to play a cooperative or redundant role in angiogenesis with EDG-1.
For Academic pricing please login or contact us at discoverysciences@invitrogen.com.
Spezifikation
| NM_005226.2 | |
| Teilende Zellen | |
| Fluoreszent | |
| EDG3 | |
| Auf Einzelzellen basierende Klone | |
| 2 x 106 Zellen | |
| EDG3 | |
| 293T (HEK) | |
| GPCRs |
| Zellbasiertes Beta-Lactamase-Reportergen | |
| Inhalt: K1713 GeneBLAzer™ EDG3-Gα15-NFAT-bla HEK293T-Zellen (LiveBLAzer™-FRET B⁄G Ladekit, Lösung D und andere Materialien sind separat erhältlich; siehe Protokoll). Enthält: • GeneBLAzer™ EDG3-Gα15-NFAT-bla HEK293T-Zellen • GeneBLAzer™ EDG3-Gα15-NFAT-bla HEK293T Assay-Protokoll • Analysenzertifikat Lagerung: Die GeneBLAzer™ EDG3-Gα15-NFAT-BLA HEK293T-Zellen werden auf Trockeneis geliefert und sollten sofort nach Erhalt in flüssigem Stickstoff gelagert werden. |
|
| FRET | |
| EDG3-Galpha15-NFAT-bla HEK293T-Zellen, EDG3-Galpha15-NFAT-bla HEK293T Assay-Protokoll, Analysenzertifikat | |
| GeneBLAzer™ | |
| BLA (Beta-Lactamase) | |
| Teilende Zellen | |
| GeneBLAzer™ |
Nur für Forschungszwecke. Nicht zur Verwendung bei diagnostischen Verfahren.