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Gemcitabine hydrochloride, Tocris Bioscience™

Artikelnummer. 30001393
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Menge:
10 mg
50 mg
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Beschreibung

DNA synthesis inhibitor

Deoxycytidine analog that inhibits DNA synthesis. Metabolized to form gemcitabine triphosphate (dFdCTP) and gemcitabine diphosphate (dFdCDP). dFdCTD inhibits ribonucleotide reductase causing a reduction in cellular nucleotides. dFdCTP is incorporated in DNA resulting in DNA strand termination. Displays antitumor activity in vitro and in vivo.

Chemische Identifikatoren

CAS 122111-03-9
Summenformel C9H12ClF2N3O4
Molekulargewicht (g/mol) 299.659
InChI-Schlüssel OKKDEIYWILRZIA-OSZBKLCCSA-N
Synonym gemcitabine hcl, 2',2'-difluorodeoxycytidine monohydrochloride, 2'-deoxy-2',2'-difluorocytidine hydrochloride, 2 1h-pyrimidinone, 4-amino-1-2-deoxy-2,2-difluoro-d-erythro-pentofuranosyl
PubChem CID 44558863
ChEBI CHEBI:31647
IUPAC-Name 4-amino-1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one;hydron;chloride
SMILES [H+].C1=CN(C(=O)N=C1N)C2C(C(C(O2)CO)O)(F)F.[Cl-]

Spezifikation

Chemischer Name oder Material Gemcitabine hydrochloride
Menge 10 mg
Formelmasse 299.66
Reinheit (%) >99%
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