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Fluticasone propionate, Tocris Bioscience™

Artikelnummer. 18772674
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Menge:
10 mg
50 mg
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Beschreibung

Selective high affinity glucocorticoid receptor agonist

High affinity, selective glucocorticoid receptor agonist (Kd = 0.5 nM). Potently stimulates glucocorticoid receptor-mediated transactivation of gene expression and enhances human eosinophil apoptosis (EC50 = 3.7 nM) in vitro. Inhibits mast cell accumulation in nasal mucosa following topical administration. Lipophilic anti-inflammatory agent with low oral bioavailability. Also potentiates KV1 channels (EC50 = 37 nM).

Chemische Identifikatoren

CAS 80474-14-2
Summenformel C25H31F3O5S
Molekulargewicht (g/mol) 505.604
InChI-Schlüssel WMWTYOKRWGGJOA-AMTWIDTLSA-N
Synonym fluticasone propionate-d5, fluticasone propionate d5, fluticasone propionate/, fluticasone-d5 propionate
PubChem CID 91820603
IUPAC-Name [(6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-17-(fluoromethylsulfanylcarbonyl)-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] 2,2,3,3,3-pentadeuteriopropanoate
SMILES CCC(=O)OC1(C(CC2C1(CC(C3(C2CC(C4=CC(=O)C=CC43C)F)F)O)C)C)C(=O)SCF

Spezifikation

Chemischer Name oder Material Fluticasone propionate
Menge 50 mg
Formelmasse 500.57
Reinheit (%) >98%
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