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DACH1 Rabbit anti-Human, CoraLite 488, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Marke: Proteintech CL488-10914-100UL
Additional Details : Gewicht : 0.00010kg
Beschreibung
DACH1, a homologue of the Drosophila dachshund gene, is a key regulator of cell fate determination during eye, leg, and brain development in the fly. Through interacting with NCoR and Smad4, DACH1 is able to inhibit the transforming growth factor-beta (TGF-beta) signaling pathway. DACH1 can inhibit breast cancer cellular proliferation via cyclin D1, suggesting a possible role in tumor suppression. Additionally, DACH1 plays an important role in negative regulation of RANKL (Receptor activator of NF-kappaB ligand ) gene expression in marrow stromal/preosteoblast cells, and loss of DACH1 expression might be involved in endometrial cancer progression. Four isoforms of DACH1 are produced by alternative splicing. This antibody is a rabbit polyclonal antibody raised against residues near the C terminus of human DACH1.
Spezifikation
| DACH1 | |
| Polyclonal | |
| CoraLite 488 | |
| 100 μL | |
| 1602 | |
| Liquid |
| Immunofluorescence | |
| 1000 μg/mL | |
| Rabbit | |
| Primary | |
| Human | |
| IgG |