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c-Met Monoclonal Antibody (A9A5), Invitrogen™
Mouse Monoclonal Antibody
Marke: Invitrogen MA550613
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Beschreibung
Positive control: A549 cell lysate, HepG2 cell lysate, human lung carcinoma tissue. Predicted band size: 156 kDa Subcellular Location: Membrane; Secreted.
MET (cMET) is a receptor-like tyrosine kinase whose dysregulation has been linked to many types of human malignancies. After activation of the ligand, MET interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, and STAT3. There interactions lead to the activation of signaling cascades including RAS-ERK, PI3, kinase-AKT, and PLCgamma-PKC. MET plays a role in embryonic development including gastrulation, development of muscles and neurons, angiogenesis, and kidney formation. It also plays a role in adults including wound healing, organ regeneration, and tissue remodeling. MET has been linked to cancers including gastric, renal, and breast; therefore, making it a target for cancer therapeutics and diagnostic testing.
Spezifikation
| c-Met | |
| Monoclonal | |
| 1 mg/mL | |
| PBS with 0.1% BSA, 40% glycerol and 0.05% sodium azide; pH 7.4 | |
| P08581 | |
| MET | |
| Synthetic peptide within Human c-Met aa 1341-1390/1390. | |
| 100 μL | |
| Primary | |
| Human | |
| Liquid |
| Immunohistochemistry (Paraffin), Western Blot | |
| A9A5 | |
| Unconjugated | |
| MET | |
| AI838057, AUTS9, bHLHe59, CG1705, CG1705-PA, CG1705-PB, cmet, c-met, c-met proto-oncogene, c-Met receptor tyrosine kinase, c-Met/HGF receptor, D249, DFNB97, Dmel\CG1705, Dmel_CG1705, DmMet, EC 2.7.10.1, Hepatocyte growth factor receptor, HGF, HGF receptor, HGF receptor c-Met, HGF/SF receptor, HGFR, HGF-SF receptor, juvenile hormone resistance, met, met proto-oncogene, met proto-oncogene (hepatocyte growth factor receptor), met proto-oncogene tyrosine kinase, MET proto-oncogene, receptor tyrosine kinase, Met/Met1, Met, protein tyrosin kinase, methoprene tolerant, Methoprene-tolerant, Methoprene-tolerant protein, Met-PA, Met-PB, Mett, oncogene MET, Par4, Proto-oncogene c-Met, RCCP2, resistance (1) juvenile H, resistance to juvenile hormone, Rst(1)JH, sc MET, scatter factor receptor, SF receptor, soluble c met, tyrosine-protein kinase Met | |
| Mouse | |
| Protein A | |
| RUO | |
| 4233 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| IgG1 |
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