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BX 795, Tocris Bioscience™

Artikelnummer. 18065072
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Menge:
10 mg
50 mg
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Beschreibung

PDPK1 (PDK1) inhibitor

Inhibitor of 3-phosphoinositide-dependent kinase 1 (PDPK1). Inhibits Akt phosphorylation at Thr308 in PC3 cells; also inhibits anchorage-independent growth of PC3 and MDA-MB-468 cells. Exhibits activity at other kinases, including TANK-binding kinase 1 (TBK1), Aurora B and IκB kinase ε (IKKε). Also enhances lentiviral transduction of natural killer (NK) cells by around 3.8-fold.

Chemische Identifikatoren

CAS 702675-74-9
Summenformel C23H26IN7O2S
Molekulargewicht (g/mol) 591.47
MDL-Nummer MFCD12546134
InChI-Schlüssel VAVXGGRQQJZYBL-UHFFFAOYSA-N
Synonym n-3-5-iodo-4-3-2-thienylcarbonyl amino propyl amino-2-pyrimidinyl amino phenyl-1-pyrrolidinecarboxamide, n-3-5-iodo-4-3-thiophene-2-carbonylamino propylamino pyrimidin-2-yl amino phenyl pyrrolidine-1-carboxamide, n-3-4-3-thiophene-2-carbonylamino propylamino-5-iodopyrimidin-2-ylamino phenyl pyrrolidine-1-carboxamide, n-3-5-iodo-4-3-thiophene-2-carboxamido propylamino pyrimidin-2-ylamino phenyl pyrrolidine-1-carboxamide, n-3-5-iodo-4-3-thiophen-2-ylcarbonyl amino propyl amino pyrimidin-2-yl amino phenyl pyrrolidine-1-carboxamide, n-3-5-iodo-4-3-thiophen-2-ylformamido propyl amino pyrimidin-2-yl amino phenyl pyrrolidine-1-carboxamide, bx7, d0rg0z, n-3-5-iodo-4-3-thiophene-2-carboxamido propyl amino pyrimidin-2-yl amino phenyl pyrrolidine-1-carboxamide, n-3-4-2-2-formamidothiophen-3-yl propanamido-5-iodopyrimidin-2-ylamino phenyl pyrrolidine-1-carboxamide
PubChem CID 10077147
IUPAC-Name N-(3-{[5-iodo-4-({3-[(thiophen-2-yl)formamido]propyl}amino)pyrimidin-2-yl]amino}phenyl)pyrrolidine-1-carboxamide
SMILES IC1=CN=C(NC2=CC(NC(=O)N3CCCC3)=CC=C2)N=C1NCCCNC(=O)C1=CC=CS1

Spezifikation

Chemischer Name oder Material BX 795
Menge 10 mg
Formelmasse 591.47
Reinheit (%) >98%
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