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ARRY 520 trifluoroacetate, Tocris Bioscience™

Artikelnummer. 30001682
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Menge:
10 mg
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Beschreibung

Potent and selective kinesin spindle protein (KSP) inhibitor; induces Mcl-1 degradation

Potent kinesin spindle protein (KSP) inhibitor (IC50 = 6 nM); selective for KSP over >250 other receptors and kinases at a concentration of 10 μM. Displays robust antitumor activity in bortezomib-resistant xenografts either alone or in combination with bortezomib. Induces degradation of Mcl-1; exhibits comparable cytotoxic activity to taxol (Cat. No. 1097) in epithelial ovarian cancer cells. Active in vivo.

Spezifikation

Chemischer Name oder Material ARRY 520 trifluoroacetate
CAS 885060-09-3
Summenformel C20H22F2N4O2S
Menge 10 mg
Synonym arry-520, filanesib, unii-8a49oso368, arry 520 trifluoroacetate, 2s-2-3-aminopropyl-5-2,5-difluorophenyl-n-methoxy-n-methyl-2-phenyl-1,3,4-thiadiazole-3 2h-carboxamide, arry 520, filanesib inn, filanesib usan:inn, arry520, arry-520; filanesib
InChI-Schlüssel LLXISKGBWFTGEI-FQEVSTJZSA-N
SMILES CN(C(=O)N1C(SC(=N1)C2=C(C=CC(=C2)F)F)(CCCN)C3=CC=CC=C3)OC
IUPAC-Name (2S)-2-(3-aminopropyl)-5-(2,5-difluorophenyl)-N-methoxy-N-methyl-2-phenyl-1,3,4-thiadiazole-3-carboxamide
Molekulargewicht (g/mol) 420.479
PubChem CID 44224257
Formelmasse 420.48
Reinheit (%) >98%
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