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  8. (±)-AMG 487, Tocris Bioscience™

(±)-AMG 487, Tocris Bioscience™

Artikelnummer. 30001673
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Menge:
10 mg
50 mg
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Beschreibung

CXCR3 antagonist; inhibits cell migration and metastasis

(±)-AMG 487 is an antagonist of CXCR3; inhibits binding of 125I-IP-10 and 125I-ITAC to CXCR3 (IC50 values are 8.0 and 8.2 nM respectively). Inhibits CXCR3-mediated cell migration by the chemokines IP-10, ITAC and MiG in vitro (IC50 values are 8, 15 and 36 nM respectively). Also shown to inhibit lung metastasis in a mouse model of metastatic breast cancer.

This product is racemic.

Chemische Identifikatoren

CAS 947536-03-0
Summenformel C32H28F3N5O4
Molekulargewicht (g/mol) 603.602
InChI-Schlüssel WQTKNBPCJKRYPA-UHFFFAOYSA-N
Synonym n-1r-1-3-4-ethoxyphenyl-4-oxopyrido 2,3-d pyrimidin-2-yl ethyl-n-pyridin-3-ylmethyl-2-4-trifluoromethoxy phenyl acetamide, n-1-3-4-ethoxyphenyl-3,4-dihydro-4-oxopyrido 2,3-d pyrimidin-2-yl ethyl-n-3-pyridinylmethyl-4-trifluoromethoxy benzeneacetamide
PubChem CID 10282265
IUPAC-Name N-[1-[3-(4-ethoxyphenyl)-4-oxopyrido[2,3-d]pyrimidin-2-yl]ethyl]-N-(pyridin-3-ylmethyl)-2-[4-(trifluoromethoxy)phenyl]acetamide
SMILES CCOC1=CC=C(C=C1)N2C(=O)C3=C(N=CC=C3)N=C2C(C)N(CC4=CN=CC=C4)C(=O)CC5=CC=C(C=C5)OC(F)(F)F

Spezifikation

Chemischer Name oder Material (±)-AMG 487
Menge 50 mg
Formelmasse 603.59
Reinheit (%) >98%
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