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6-Thioguanine, Tocris Bioscience™

Artikelnummer. 18792784
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Menge:
50 mg
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Beschreibung

Anticancer and immunosuppressive agent

Anticancer and immunosuppressive agent often used to treat immune disorders and leukemia. Displays cytotoxic and antineoplastic properties; disrupts cytosine methylation by DNA methyltransferases after incorporation into DNA. Selectively kills BRCA2-defective tumors in a xenograft model. Also facilitates proteasome-mediated degradation of DNA (cytosine-5)-methyltransferase 1 (DNMT1). Also inhibits SARS-CoV papain-like protease (PLpro; IC50 = 5 μM for PLpro deubiquitination activity).

Spezifikation

Chemischer Name oder Material 6-Thioguanine
CAS 154-42-7
Summenformel C5H5N5S
MDL-Nummer MFCD00233553
Menge 50 mg
Synonym 6-thioguanine, thioguanine, tioguanine, 2-amino-6-mercaptopurine, 6-mercaptoguanine, tioguanin, tabloid, lanvis, 2-amino-6-purinethiol, 2-aminopurine-6-thiol
InChI-Schlüssel WYWHKKSPHMUBEB-UHFFFAOYSA-N
SMILES NC1=NC(=S)C2=C(N1)N=CN2
IUPAC-Name 2-Amino-6,7-dihydro-3H-purin-6-thion
Molekulargewicht (g/mol) 167.19
PubChem CID 2723601
ChEBI CHEBI:9555
Formelmasse 167.19
Reinheit (%) >99%
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